Molecular targets for NF1-associated malignant peripheral nerve sheath tumor
نویسندگان
چکیده
منابع مشابه
Intrathoracic Malignant Peripheral Nerve Sheath Tumor: Histopathological and Immunohistochemical Features
Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessne...
متن کاملMalignant peripheral nerve sheath tumors (MPNST) in NF1-affected children.
BACKGROUND Malignant peripheral nerve sheath tumors (MPNST) constitute a heterogeneous group of malignant tumors that probably arise from cells of the peripheral nerve sheath. Association of MPNST with neurofibromatosis type 1 (NF1) is frequently reported. MPNST contribute significantly to the reduced life-span of NF1-patients. At present there are only sparse data on MPNST in NF1-children. The...
متن کاملMalignant peripheral nerve sheath tumor of kidney.
A 40-year-old man presented with complaints of left-sided lower back discomfort for 2 to 3 months. There was no other significant history. Physical examination was unremarkable except for a palpable mass in the left flank. Ultrasonography showed a hypoechoic mass. Biphasic contrast-enhanced computerized tomogram revealed a large, heterogenous, infiltrating, necrotic mass lesion arising from the...
متن کاملMassive exophytic malignant peripheral nerve sheath tumor
We present a case of a solitary neurofibroma involving the right posterior shoulder of a 69-year-old man with degeneration into a massive, malignant peripheral nerve sheath tumor measuring more than 3 times the average reported size. The radiographic, magnetic resonance imaging, and computed tomographic features are compared with the gross appearance and pathology.
متن کاملIntrathoracic paraspinal malignant peripheral nerve sheath tumor.
Schwannoma is the most common nerve sheath tumor in the posterior mediastinum, whereas intrathoracic paraspinal malignant peripheral nerve sheath tumor (MPNST) is quite rare. Both benign and malignant nerve sheath tumors may be symptomatic, rendering clinical differentiation of limited utility. On radiographic imaging, erosion of the ribs and vertebral bodies, irregularity in contour, and inhom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reports of Practical Oncology & Radiotherapy
سال: 2020
ISSN: 1507-1367
DOI: 10.1016/j.rpor.2020.04.010